![]() ![]() The humanized R451C mutation in mice did not result in apparent autism‐like phenotypes, but produced detectable functional consequences that may be interpreted in terms of physical development and/or reduced sensitivity to stimuli.Reflex Arena is an old-school arena shooter that updates the dizzying speed and demanding precision of a classic arena FPS with the power of modern gaming technology. Significant differences in N元 adults included somewhat longer latencies to fall from the rotarod, less vertical activity in the open field, and less acoustic startle to high decibel tones. Minor developmental differences were detected between N元 and WT, including slightly different rates of somatic growth, slower righting reflexes at postnatal days 2–6, faster homing reflexes in females, and less vocalizations on postnatal day 8 in males. Physical and procedural abilities were similar across genotypes on measures of general health, sensory abilities, sensorimotor gating, motor functions, and anxiety‐related traits. ![]() No differences between N元 and their wildtype (WT) littermate controls were detected on measures of juvenile reciprocal social interaction, adult social approach, cognitive abilities, and resistance to change in a spatial habit, findings which were replicated in several cohorts of males and females. Mice with the human R451C mutation (N元), identical to the point mutation found in two brothers with autism spectrum disorders, were generated and phenotyped in multiple behavioral assays with face validity to the diagnostic symptoms of autism. ![]() Neuroligin‐3 is a member of the class of cell adhesion proteins that mediate synapse development and have been implicated in autism. Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin miceĬhadman, Kathryn K. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |